MINERVA 12.2 release

We are happy to announce the new release of MINERVA platform, which hosts the PD map.
Details about the changes and bug fixes can be found in the release notes.
Here, we’d like to highlight the features that the PD map users may find the most interesting.

Pre-loaded plugins

The plugins button now displays the list of pre-loaded plugins, easy to start and use. Currently available are:

Pre-loaded plugins

Uploaded genetic variants match their protein structure

In the earlier MINERVA release we introduced handling overlays of genetic variants (if you’re interested, take a look here). Now, for the variants affecting the protein-coding regions, MINERVA links them to the structures displayed in MolArt. We have prepared a small example to illustrate this functionality. This file contains an example overlay with 42 PRKN variants, annotated by Proteins API. Take a look at the screenshot below, showing the structure of the Parkin (PRKN) dimer. Besides the regular panel of annotations available via MolArt, the dataset MINERVA overlay - PRKN variants example is available (marked by red rectangle). Selecting it shows only the variants of this overlay and allows highlighting them. In the image below, the (C289G variant)[https://www.ncbi.nlm.nih.gov/pubmed/20889486] is selected, and its position in the PRKN structure is automatically highlighted (marked by red circles). The right panel is shown in two versions with different opacity set by the slider below the structure.


SBML support

The support of SBML by MINERVA has improved, as layout and render packages are now handled. Exports of the PD map contents to SBML will preserve the layout of the map. We hope this will help to advance construction of detailed, mechanistic models of PD pathogenesis.

We hope you’ll enjoy the new features of MINERVA in exploring the PD map.

Marek Ostaszewski